IDIOPATIK TROMBOSITOPENIA PURPURA ADALAH PDF

Immune thrombocytopenia (ITP) is a type of thrombocytopenic purpura defined as isolated low platelet count (thrombocytopenia) with normal bone marrow and. Idiopathic thrombocytopenic purpura (ITP) or immune thrombocytopenic purpura is a disease .. Purwanto I. Purpura trombositopenia idiopatik. In: Sudoyo AW. Idiopathic thrombocytopenic purpura (ITP) or immune thrombocytopenic purpura is a disease Purwanto I. Purpura trombositopenia idiopatik.

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Immune thrombocytopenic purpura – Wikipedia

All the petechial lesions were completely resolved over the neck, arm, and forearms. Chemistry of Plants That Changed the World. Uncommon findings are gastrointestinal GI bleeding, gross hematuria and intracranial hemorrhage.

Patient started treatment 7 years back and was on tablet isosorbide dinitrate 10 mg, tablet atenelol 25 mg, tablet envas 5 mg and patient had discontinued aspirin 6 months back. Petechial spots on dorsum of tongue, petechial spot on left side hard palate and left maxillary tuberosity region.

Immune thrombocytopenic purpura (ITP): MedlinePlus Medical Encyclopedia

This smear demonstrates the absence of immature leukocytes as in leukemia and fragmented erythrocytes as in thrombotic avalah purpura and no clumps of platelets as in pseudothrombocytopenia. The coating of platelets with IgG renders them susceptible to opsonization and phagocytosis by splenic macrophagesas well by Kupffer cells in the liver. People with the disease have too few platelets in the blood. Management of ITP is based on platelet count and severity of bleeding.

Many older recommendations suggested a certain platelet count threshold usually somewhere below Despite the destruction of platelets by splenic macrophages, the spleen is normally not enlarged. Open in a separate window. Despite the destruction of platelets by splenic macrophages, the spleen is normally not enlarged.

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Platelet transfusion alone is normally not recommended except in an emergency, and is usually unsuccessful in producing a long-term platelet count increase. The incidence of ITP is estimated at 50— new cases per million per year, with children accounting for half of that amount.

Bleeding time is usually prolonged in ITP patients. The exact mechanism by which dapsone assists in ITP is unclear. In chronic refractory cases, where immune pathogenesis has been confirmed, [15] the off-label use of the vinca alkaloid [16] [17] [18] and chemotherapy agent vincristine may be attempted. The diagnosis of ITP is a diagnosis of exclusion.

There is increasing use of immunosuppressants such as mycophenolate mofetil and azathioprine because of their effectiveness. The spleen is the site of autoantibody production white pulp ; it is also the site of phagocytosis of autoantibody-coated platelets red pulp. Br J Haematol ; Background Idiopathic thrombocytopenic purpura ITPalso known as primary pirpura thrombocytopenic idlopatik and autoimmune thrombocytopenic purpura, is defined as isolated thrombocytopenia with normal bone marrow and in the absence of other causes of thrombocytopenia.

Current guidelines recommend treatment only in cases of significant bleeding. ABC of clinical haematology. To date, the diagnosis of ITP is still arrived at by exclusion, i. With rare exceptions, there is usually no need to treat based on platelet counts.

The purpuar marrow is usually normal or shows increased megakaryocytes. Archived from the original on Initial laboratory findings useful for predicting the diagnosis of idiopathic thrombocytopenic purpura.

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Immune thrombocytopenic purpura (ITP)

Bleeding time from minor lacerations or abrasions is usually prolonged. Rarely, splenectomy may be required to manage acute hemorrhage [ 19 ]. First, it has to be determined that there are no blood abnormalities other than a low platelet count, and no physical signs other than bleeding.

Conclusion The initial treatment of ITP includes: Our case was abrupt and acute in onset.

Idiopathic thrombocytopenic purpura

However, while sometimes effective, it is costly and produces improvement that generally lasts less than a month. This page was last edited on 27 Septemberat Platelet transfusions may be used in severe bleeding together with a very low count. Diseases of platelet number: Such secondary causes include leukemiamedications e. Hematoma, idiopathic thrombocytopenic purpura, petechiae, platelets.

In adults, it is more often a long-term chronic disease and can occur after a viral infection, with use of certain drugs, during pregnancy, or as part of an immune disorder.

A report of 66 cases. Chronic idiopathic thrombocytopenic purpura: FDA extends use of Promacta in young children with rare idiopxtik disorder. Bleeding time is prolonged in ITP patients; however, the use of bleeding time in diagnosis is discouraged by the American Society of Hematology practice guidelines as useless. The body destroys the platelets that carry the antibodies. Foreign Atopic eczema Allergic urticaria Allergic rhinitis Hay fever Allergic asthma Anaphylaxis Food allergy common allergies include: Once the platelet count has improved, the dose of steroid is gradually reduced while the possibility of relapse is monitored.